In a natural setting, our diets would be providing our body's cells the building blocks they require to generate their own glutathione.
Unfortunately, modern food processing and delivery removes many of the nutritional benefits that we require for healthy living.
In order to understand how this happens with glutathione we need to understand a little science. Glutathione is made up of three amino acids- cysteine, glycine and glutamate. With modern food processing today, most of our diets provide sufficient amounts of glutamate and glycine. The missing link is cysteine.
A natural way to provide cysteine to the cell is through ingestion of bonded cystine (note
missing "e"). Bonded cystine is composed of two cysteine molecules linked by a
disulfide bond. What this means is that this bonded cystine travels
safely through the digestive system and blood plasma and upon entering
the cell is reduced to two cysteine molecules, which become available
for glutathione production.
Bonded cystine is found naturally in some unheated food stuffs- raw eggs, raw meats, some raw vegetables and
minimally processed dairy products. However in the process of cooking, normal
dairy pasteurization and mechanical agitation, the fragile cystine bond
is broken. When this happens, the cell does not receive the nutrition
it needs for glutathione production.
Undenatured dairy products are our best bet for natural glutathione production.
NAC (n-acetyl-cysteine) is
currently available in health food stores and does raise glutathione.
There are however two common issues with the use of NAC as a
supplement: It creates rapid glutathione peaks and declines quickly, thus requiring multiple daily dosing. The second reason is that it is a pharmaceutical drug and can cause adverse effects including
rash, wheezing, nausea, vomiting, cramps and diarrhea due to toxicity.
It is used in regulated clinical situations under medical supervision.
A 1992 clinical study shows that oral glutathione supplementation (L-glutathione) does not significantly raise inter cellular glutathione. Our body's digestive system breaks L-glutathione down and makes it unusable at the cellular level. A commonly available supplement, L-cysteine, does not represent an ideal delivery system as it also oxidizes in the digestive tract, is potentially toxic and may only raise glutathione levels minimally.
The Standard Physicians Desk Reference shows only one natural clinically validated option to raise glutathione levels in patients:
Natural dietary whey protein isolate using a patented extraction process which is sold under the brand name Immunocal. Over 80 gallons of milk are required for each box!
Natural dietary whey protein isolate is lactose free, has no listed side effects and is currently being used in multiple clinical studies. It is clinically documented to raise inter cellular glutathione levels.
Note that this is not standard "whey protein". Special patented extraction methods are used so as to not compromise the bonded cystine component of the isolate.
Common whey proteins will not work! It must have bonded cystine!